Applications of FM Noise Radar Waveforms: Spatial Modulation and Polarization Diversity

Two possible radar application spaces are explored through the exploitation of highdimensional nonrecurrent FM-noise waveforms. The first involving a simultaneous dual-polarized emission scheme that provides good separability with respect to co- and cross-polarized terms and the second mimicking the passive actuation of the human eye with a MIMO emission. A waveform optimization scheme denoted as pseudorandom optimized (PRO) FM has been shown to generate FM-noise radar waveforms that are amenable to high power transmitters. Each pulse is generated and optimized independently and possesses a non-repeating FM-noise modulation structure. Because of this the range sidelobes of each pulse are unique and thus are effectively suppressed given enough coherent integration. The PRO-FM waveform generation scheme is used to create two independent sets of FM-noise waveforms to be incorporated into a simultaneous dual-polarized emission; whereby two independent PRO-FM waveforms will be transmitted simultaneously from orthogonal polarization channels. This effectively creates a polarization diverse emission. The random nature of these waveforms also reduce cross-correlation effects that occur during simultaneous transmission on both channels. This formulation is evaluated using experimental open-air measurements to demonstrate the effectiveness of this high-dimensional emission. This research aims to build upon previous work that has demonstrated the ability to mimic fixational eye movements (FEM) employed by the human eye. To implement FEM on a radar system a MIMO capable digital array must be utilized in conjunction with spatial modulation beamforming. Successful imitation of FEM will require randomized fast-time beamsteering from a two-dimensional array. The inherent randomness associated with FEM will be paired with the PRO-FM waveforms to create an emission possessing randomness in the space and frequency domains, called the FEM radar (FEMR). Unlike traditional MIMO, FEMR emits a coherent and time varying beam. Simulations will show the inherent enhancement to spatial resolution in two-dimensional space (azimuth and elevation) relative to standard beamforming using only the matched filter to process returns

Coherent diffraction of single Rice Dwarf virus particles using hard X-rays at the Linac Coherent Light Source

Single particle diffractive imaging data from Rice Dwarf Virus (RDV) were recorded using the Coherent X-ray Imaging (CXI) instrument at the Linac Coherent Light Source (LCLS). RDV was chosen as it is a wellcharacterized model system, useful for proof-of-principle experiments, system optimization and algorithm development. RDV, an icosahedral virus of about 70 nm in diameter, was aerosolized and injected into the approximately 0.1 mu m diameter focused hard X-ray beam at the CXI instrument of LCLS. Diffraction patterns from RDV with signal to 5.9 angstrom ngstrom were recorded. The diffraction data are available through the Coherent X-ray Imaging Data Bank (CXIDB) as a resource for algorithm development, the contents of which are described here.11Ysciescopu

The auditory cortex of the bat Phyllostomus discolor: Localization and organization of basic response properties

<p>Abstract</p> <p>Background</p> <p>The mammalian auditory cortex can be subdivided into various fields characterized by neurophysiological and neuroarchitectural properties and by connections with different nuclei of the thalamus. Besides the primary auditory cortex, echolocating bats have cortical fields for the processing of temporal and spectral features of the echolocation pulses. This paper reports on location, neuroarchitecture and basic functional organization of the auditory cortex of the microchiropteran bat <it>Phyllostomus discolor </it>(family: Phyllostomidae).</p> <p>Results</p> <p>The auditory cortical area of <it>P. discolor </it>is located at parieto-temporal portions of the neocortex. It covers a rostro-caudal range of about 4800 μm and a medio-lateral distance of about 7000 μm on the flattened cortical surface.</p> <p>The auditory cortices of ten adult <it>P. discolor </it>were electrophysiologically mapped in detail. Responses of 849 units (single neurons and neuronal clusters up to three neurons) to pure tone stimulation were recorded extracellularly. Cortical units were characterized and classified depending on their response properties such as best frequency, auditory threshold, first spike latency, response duration, width and shape of the frequency response area and binaural interactions.</p> <p>Based on neurophysiological and neuroanatomical criteria, the auditory cortex of <it>P. discolor </it>could be subdivided into anterior and posterior ventral fields and anterior and posterior dorsal fields. The representation of response properties within the different auditory cortical fields was analyzed in detail. The two ventral fields were distinguished by their tonotopic organization with opposing frequency gradients. The dorsal cortical fields were not tonotopically organized but contained neurons that were responsive to high frequencies only.</p> <p>Conclusion</p> <p>The auditory cortex of <it>P. discolor </it>resembles the auditory cortex of other phyllostomid bats in size and basic functional organization. The tonotopically organized posterior ventral field might represent the primary auditory cortex and the tonotopically organized anterior ventral field seems to be similar to the anterior auditory field of other mammals. As most energy of the echolocation pulse of <it>P. discolor </it>is contained in the high-frequency range, the non-tonotopically organized high-frequency dorsal region seems to be particularly important for echolocation.</p

Enzyme intermediates captured on the fly by mix-and-inject serial crystallography

Background Ever since the first atomic structure of an enzyme was solved, the discovery of the mechanism and dynamics of reactions catalyzed by biomolecules has been the key goal for the understanding of the molecular processes that drive life on earth. Despite a large number of successful methods for trapping reaction intermediates, the direct observation of an ongoing reaction has been possible only in rare and exceptional cases. Results Here, we demonstrate a general method for capturing enzyme catalysis in action by mix-and-inject serial crystallography (MISC). Specifically, we follow the catalytic reaction of the Mycobacterium tuberculosis β-lactamase with the third-generation antibiotic ceftriaxone by time-resolved serial femtosecond crystallography. The results reveal, in near atomic detail, antibiotic cleavage and inactivation from 30 ms to 2s. Conclusions MISC is a versatile and generally applicable method to investigate reactions of biological macromolecules, some of which are of immense biological significance and might be, in addition, important targets for structure-based drug design. With megahertz X-ray pulse rates expected at the Linac Coherent Light Source II and the European X-ray free-electron laser, multiple, finely spaced time delays can be collected rapidly, allowing a comprehensive description of biomolecular reactions in terms of structure and kinetics from the same set of X-ray data.This work was supported by the National Science Foundation (NSF)-Science and Technology Center (STC) BioXFEL through award STC-1231306, and in part by the US Department of Energy, Office of Science, Basic Energy Sciences under contract DE-SC0002164 (to A.O., algorithm design and development) and by the NSF under contract number 1551489 (to A.O., underlying analytical models). Portions of this research were performed at the Linac Coherent Light Source (LCLS). Use of the LCLS, SLAC National Accelerator Laboratory, is supported by the US Department of Energy, Office of Science, Basic Energy Sciences under contract DE-AC02-76SF00515. This material is based upon work supported by the NSF Graduate Research Fellowship Program to J.L.O. under grant no. 1450681. The work was also supported by funds from the National Institutes of Health grants R01 GM117342-01 and R01 GM095583, by funds from the Biodesign Center for Applied Structural Discovery at Arizona State University, and the US Department of Energy through Lawrence Livermore National Laboratory under contract DE-AC52-07NA27344. Part of this work was also supported by program-oriented funds of the Helmholtz Association

Hacking code/space: Confounding the code of global capitalism

Information-technologies are essential for global capitalism to function at speed across scale, space and complexity. The importance of software and algorithms in the governance of these systems is reflected in the attention of scholars to the ways digital code and materiality (re)combine to create hybrid digital/material spaces of economic activity, movement and everyday life. This paper extends this work in two key ways: first by emphasising the relational aspect of these code/ spaces, and second by showing how the digital algorithms of code/spaces are hackable rather than hegemonic. Using the case study of frequent flyer programmes we demonstrate how networked knowledge-sharing reshapes code/spaces to provide unintended opportunities such as low-cost travel and access to spaces normally only frequented by global elites. Although this case highlights vulnerabilities in the code of global capitalism, it is primarily only those with significant lifestyle privilege who are able to fully participate in these subversions. Moreover, while much of the value captured by “airline hackers” comes from airlines’ profit margins, the relationality of code/spaces can impact citizens and consumers not directly connected to or interested in airline travel. Ultimately, this paper demonstrates that in contrast to characterisations of omnipresence and hegemony, the information networks and algorithms of global capitalism contain moments of uneven porousness and selective hackability